Empirical determination of the degree of analgesic activity of some new 3-aminothieno[2,3-b]pyridines and 1,4-dihydropyridines based on a complex criterion

Introduction: It is revelant to solve the problem of anesthesia based on research new highly effective and safe medicines. Among modern studies, preparation heterocyclic compounds starting from cyanothioacetamide with analgesic anti-inflammatory activities considerable interest. Materials Methods: болевой синдром Results: shown that all studied 1,4-dihydropyridines condensed thieno[2,3-b]pyridines reveal activity varying degrees severity, values criterion Anat. Discussion: was found most pronounced by three samples: AZ-023, AZ-331 AZ-383. The complex Anat for animals receiving a sample AZ-023 50.1, exceeding indicator in comparison group 42 times. this had received samples AZ-383 were highest, namely 64.3 68.4, which 53 57 times higher than sodium metamizole, respectively. Conclusion: obtained results advantage over reference drug determine expediency further preclinical studies detailed study their acute chronic toxicity, as well hepato-, nephro-, hemato- gastrotoxicity. Graphical Abstract